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Atividade ulcerogênica do celecoxibe, piroxicam e piroxicam associado a sulfato de zinco em modelo de granuloma em ratos

Author(s): Janaina do Amaral Bueno | Raphael Fernando Boiati | Fabiana Gatti de Menezes | Jorge Willian Leandro Nascimento

Journal: ConScientiae Saúde
ISSN 1677-1028

Volume: 9;
Issue: 1;
Start page: 79;
Date: 2010;
Original page

Objectives: The aim of this study was to evaluate the ulcerogenic activity of celecoxib (selective COX-2), the piroxicam and piroxicam + zinc sulfate (nonselective NSAIDs). Method: It has been utilized introduction of cotton pellets in the abdominal region of rats, and by evaluating the formation of gastric lesions promoted by the model. Results: The results showed that granuloma formation did not induce gastric lesions. Conclusions: Among the drugs studied, there was a higher incidence of gastric lesions caused by piroxicam when compared with celecoxib, while the association piroxicam + zinc sulfate had lower gastric lesion, when compared to piroxicam.
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Tango Jona
Tangokurs Rapperswil-Jona