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Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus

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Author(s): Rohitesh Kumar | Ramesh Subramani | Klaus-D. Feussner | William Aalbersberg

Journal: Marine Drugs
ISSN 1660-3397

Volume: 10;
Issue: 1;
Start page: 200;
Date: 2012;
Original page

Keywords: marine sponges | aurantosides | antifungal | tetramic acid glycoside | Melophlus sp.

ABSTRACT
A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (1H NMR, 1H–1H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.
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