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Auto-antibodies in Patients with Inflammatory Bowel Disease Unclassified

Author(s): Batool Mutar Mahdi

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 3;
Start page: 189;
Date: 2011;
Original page

Keywords: Acinar Cells | Antineutrophil Cytoplasmic Antibodies | Colitis | Pancreatic | Saccharomyces cerevisiae

Background: Inflammatory bowel disease unclassified (IBDU) is considered to be anaberrant immune response with loss of tolerance to many antigens. Objective: Thispaper tries to address whether there is any value to test for auto-antibodies in suchpatients. Methods: 60 patients with inflammatory bowel disease unclassifiedparticipated in the study. Auto-antibodies to nuclear antigen, intestinal goblet cell,exocrine part of pancreatic acinar cells, perinuclear antineutrophil cytoplasmic,cytoplasmic antineutrophil cytoplasmic and Saccharomyces cerevisiae were tested andcompared to 20 ulcerative colitis (UC) patients and 30 healthy controls matched for ageand sex. Results: There was a significant difference (p=0.000) between patients andcontrol group in anti-exocrine part of pancreatic acinar cells, perinuclear antineutrophilcytoplasmic and Saccharomyces cerevisiae auto-antibodies. There was also a significantdifference between IBDU and UC patients in the auto-antibodies directed againstintestinal goblet cells, (p=0.000) exocrine part of pancreas (p=0.000) and antiSaccharomyces cerevisiae antibody (p=0.000). Conclusions: Due to the autoimmunenature of indeterminate colitis, involvement of some antigens from gastrointestinal tractor the bile system in the initiation of this disease is likely.
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