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Autoimmune thyroid diseases and Helicobacter pylori: The correlation is present only in Graves's disease

Author(s): Vincenzo Bassi | Gennaro Marino | Alba Iengo | Olimpia Fattoruso | Crescenzo Santinelli

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 18;
Issue: 10;
Start page: 1093;
Date: 2012;
Original page

Keywords: Autoimmunity | Cag-A | Graves’ disease | Hashimoto’s thyroiditis | Helicobacter pylori | Hyperthyroidism | Hypothyroidism

AIM: To investigate the correlation between autoimmune thyroid diseases (ATDs) and the prevalence of Cag-A positive strains of Helicobacter pylori (H. pylori) in stool samples. METHODS: Authors investigated 112 consecutive Caucasian patients (48 females and 4 males with Graves’ disease and 54 females and 6 males with Hashimoto’s thyroiditis HT), at their first diagnosis of ATDs. Authors tested for H. pylori in stool samples using an amplified enzyme immunoassay and Cag-A in serum samples using an enzyme-linked immunoassay method (ELISA). The results were analyzed using the two-sided Fisher’s exact test and the respective odds ratio (OR) was calculated. RESULTS: A marked correlation was found between the presence of H. pylori (P ≤ 0.0001, OR 6.3) and, in particular, Cag-A positive strains (P ≤ 0.005, OR 5.3) in Graves’ disease, but not in Hashimoto’s thyroiditis, where authors found only a correlation with Cag-A strains (P ≤ 0.005, OR 8.73) but not when H. pylori was present. CONCLUSION: The marked correlation between H. pylori and Cag-A, found in ATDs, could be dependent on the different expression of adhesion molecules in the gastric mucosa.

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