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Autonomic modulation and chronotropic activity during aerobic exercise in patients using atenolol

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Author(s): Naiane Ferraz Bandeira Alves | Suu00EAnia Karla Pacheco Porpino | Aline de Freitas Brito | Thereza Karolina Sarmento da Nu00F3brega | Rosimeire de Souza Freitas | Alexandre Su00E9rgio Silva | Manoel da Cunha Costa | Guilherme Laurentino de Lima-Filho

Journal: ConScientiae Sa├║de
ISSN 1677-1028

Volume: 10;
Issue: 1;
Start page: 51;
Date: 2011;
Original page

ABSTRACT
Introduction: The negative chronotropic effect of beta-blockers (BB) can modify itself according to its pharmacokinetics. Objective: To investigate the influence of pharmacokinetics of beta-blockers in heart rate (HR) and autonomic activity (AA) in response to the exercise. Methods: Three groups of hypertensive patients, users of atenolol (n=9), enalapril, (n=8), and a normotensive control group (n=8), performed two sessions of moderate exercise on a cycloergometer, during 40 minutes, whereby 2 hours (Session I), or 23 hours after drug administration (Session II). Records of electrocardiogram were made before, during and after the exercises. Results: The HR was lower in session I comparing with session II of the atenolol group during the exercise. There were no differences in the components of low and high frequency of AA between these sessions. Conclusions: These results confirm the negative chronotropic effect of BB. However, the absence of changes in AA suggests that other mechanisms may be contributing to this phenomenon.

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