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Avaliação da atividade anti-Trypanosoma e anti-Leishmania de Mentha arvensis e Turnera ulmifolia

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Author(s): Karla K.A. SANTOS | Edinardo F.F. MATIAS | Celestina E. SOBRAL-SOUZA | Saulo R. TINTINO | Maria F.B. MORAIS-BRAGA | Glaucia M.M. GUEDES | Miriam ROLu00D3N | Celeste VEGA | Antonieta Rojas de ARIAS | Josu00E9 G.M. COSTA | Irwin R.A. MENEZES | Henrique D.M. COUTINHO

Journal: Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas
ISSN 0717-7917

Volume: 11;
Issue: 2;
Start page: 147;
Date: 2012;
Original page

ABSTRACT
Tripanosomiasis or "Chagas disease", caused by Trypanosoma cruzi, affect 10 million people in Latin America. Today, the chemotherapy is the only specific treatment against this disease, being the most used drugs the nifurtimox and benznidazole. Leishmaniasis is a disease caused by parasites of the genus Leishmania, mainly founded in regions with forests, as the Amazonia. Recent reports about the Leishmaniasis indicate a deficit of therapeutical drugs available against this disease and reinforce the necessity of the discovering of new drugs. An interesting approach against these diseases is the use of natural products, as the extracts of plants as Mentha arvensis and Turnera ulmifolia. For the in vitro assays against T. cruzi and Leishmania, was used the clone CL-B5 and promastigote forms, respectively. The cytotoxic assay was performed using fibroblasts. Our results indicated that M. arvensis was active against all strains assayed, inhibiting 65 e 47% of the assayed strains (IC50 = 192.3 and 531.9 ¿g/mL respectively), representing an interesting and alternative source of natural products with anti-kinetoplastida activity.

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