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B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia

Author(s): Annelieke A.A. van der Linde | Ellen J.H. Schatorjé | Annemieke M. van der Weij | Eugenie F.A. Gemen | Esther de Vries

Journal: Pediatric Reports
ISSN 2036-749X

Volume: 3;
Issue: 4;
Start page: e28;
Date: 2011;
Original page

Keywords: Autoimmune hemolytic anemia | Rituximab | Child | Immune reconstitution | B-lymphocytes

We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values.
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