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Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin

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Author(s): Muftah A. M. Shushni | Rajinder Singh | Renate Mentel | Ulrike Lindequist

Journal: Marine Drugs
ISSN 1660-3397

Volume: 9;
Issue: 5;
Start page: 844;
Date: 2011;
Original page

Keywords: balticolid | antiviral | herpes simplex virus | marine fungi

ABSTRACT
A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R,11R), (4E,8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC50 value of 0.45 ┬ÁM.

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