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Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy

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Author(s): Ciofani Gianni | Danti Serena | D’Alessandro Delfo | Moscato Stefania | Petrini Mario | Menciassi Arianna

Journal: Nanoscale Research Letters
ISSN 1931-7573

Volume: 5;
Issue: 7;
Start page: 1093;
Date: 2010;
Original page

Keywords: Barium titanate nanoparticles | Glycol-chitosan | Doxorubicin | Neuroblastoma | Cancer therapy

ABSTRACT
Abstract In the latest years, innovative nanomaterials have attracted a dramatic and exponentially increasing interest, in particular for their potential applications in the biomedical field. In this paper, we reported our findings on the cytocompatibility of barium titanate nanoparticles (BTNPs), an extremely interesting ceramic material. A rational and systematic study of BTNP cytocompatibility was performed, using a dispersion method based on a non-covalent binding to glycol-chitosan, which demonstrated the optimal cytocompatibility of this nanomaterial even at high concentration (100 μg/ml). Moreover, we showed that the efficiency of doxorubicin, a widely used chemotherapy drug, is highly enhanced following the complexation with BTNPs. Our results suggest that innovative ceramic nanomaterials such as BTNPs can be realistically exploited as alternative cellular nanovectors.
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