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THE BEHAVIOUR OF THE MEMBRANARY Na+–K+–ATP–ase OF NEOPLASTIC CELLS TO THE IN VITRO CYTOSTATIC TREATMENT WITH BIOSYNTHESIS OR SEMISYNTHESIS FUROSTANOLIC-GLYCOSIDES

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Author(s): Daniela Gherghel | Pincu Rotinberg | Dorina Iurea | Pavel Chintea | Helen Rotinberg

Journal: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
ISSN 1582-3571

Volume: 6;
Issue: 1;
Date: 2005;
Original page

ABSTRACT
The in vitro short lasting antitumoral treatment of the HEp-2p and HeLa human tumoral cells with some active cytostatic furostanolic-glycoside biopreparations has induced an inhibitory impact upon Na + –K + –depending electrogenic pump. These furostanolic glycoside agents interferes, probably, direct or indirect with the membrane Na+ – K + –ase activity, either by their binding of the enzyme macromolecule or by perturbing of the energetical metabolism which leads to a decreased level of the ATP biosynthesis
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