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Behavioural Enpoints of Adult Wistar Rats, Following Aluminium Chloride Exposure

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Author(s): A.A. Buraimoh | S.A. Ojo | J.O. Hambolu | S.S. Adebisi

Journal: British Journal of Pharmacology and Toxicology
ISSN 2044-2459

Volume: 2;
Issue: 5;
Start page: 273;
Date: 2011;
Original page

Keywords: Adult | aluminium chloride | behavioural endpoints | exposure | wistar rats

ABSTRACT
Aluminium is a ubiquitous element and the third most abundant element in the earth's crust, comprising approximately 8% of the earth’s crust, exceeded only by oxygen (47%) and silicon (28%).The elemental aluminium does not occur in its pure state but is always combined with other elements such as chloride, hydroxide, silicate, sulphate and phosphate. Patients on dialysis or on long-term treatment with total parenteral nutrition have been shown to accumulate this metal in different organs. The Morris Water Maze (MWM) was described as a device to investigate spatial learning and memory as well as tools in behavioural neuroscience. The objective of this study was to determine the behavioural endpoints of wistar rats, following the aluminium chloride exposure. Total of thirty wistar rats were used in this study. The wistar rats were divided into five groups; group I was the control, group II received 475 mg/kg, group III received 950 mg/kg, group IV received 1,425 mg/kg and group V received 1,900 mg/kg via oral intubation for a duration of Eight weeks.MWM was used to test for the behaviour of the wistar rats. We observed that at the first run, the wistar rats were trying to learn task; the second and third runs rather showed that wistar rats in the control group get to the platform faster (performed the task better) than the treated groups and the difference observed was significant at p
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