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Beta-blockers and statins in the context of asthma

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Author(s): Joanna Pawlak | Ziemowit Ziętkowski | Anna Bodzenta-Łukaszyk

Journal: Postępy Higieny i Medycyny Doświadczalnej
ISSN 0032-5449

Volume: 63;
Issue: 835515;
Start page: 634;
Date: 2009;
Original page

Keywords: astma | beta-blokery | statyny

ABSTRACT
Asthma is a disease with a complex pathogenesis and differentiated clinical picture with airway inflammation in its background. Many cells and cell-released substances are engaged in the course of the disease. The basic treatment strategy in asthma is based on chronic administration of inhaled glucocorticosteroids (with a strong anti-inflammatory effect) and beta2-adrenoreceptor agonists (bronchodilatory effect). Much attention has been recently paid to the effects of other medicines on mechanisms important in the pathogenesis of asthma, including beta-blockers and statins. Many researchers have suggested a potentially useful role of some beta-blockers in chronic asthma therapy, particularly considering their effect on the pharmacodynamics of beta receptors in the bronchi. Moreover, statins, due to their anti-inflammatory and immunomodulatory effects, can also be useful in the management of asthma.
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