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Bioactive Alkaloid from Sida cordifolia Linn. with Analgesic and Anti-Inflammatory Activities

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Author(s): Ranajit Kumar Sutradhar | AKM Matior Rahman | Mesbahuddin Ahmad | Sitesh Chandra Bachar | Achinto Saha | Samar Kumar Guha

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 5;
Issue: 2;
Start page: 175;
Date: 2006;
Original page

Keywords: Sida cordifolia | Analgesic | Anti-inflammatory

ABSTRACT
In the present study, the analgesic and anti-inflammatory activities of a new alkaloid (5′-Hydroxymethyl-1′-(1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin-1-yl)-heptan-1-one) (compound 1), isolated from Sida cordifolia Linn. was investigated in animal models. The analgesic activity was investigated in the acetic acid induced writhing and the radiant heat tail flick model in mice and the carrageenan induced rat paw edema model was used for anti-inflammatory study. The compound produced significant (p

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