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Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

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Author(s): Chi-Jen Tai | Jui-Hsin Su | Ming-Shyan Huang | Zhi-Hong Wen | Chang-Feng Dai | Jyh-Horng Sheu

Journal: Marine Drugs
ISSN 1660-3397

Volume: 9;
Issue: 10;
Start page: 2036;
Date: 2011;
Original page

Keywords: soft coral | Cladiella krempfi | eunicellin-based diterpenoids | krempfielins | cytotoxic activity | anti-inflammatory activity

ABSTRACT
Four new eunicellin-based diterpenoids, krempfielins A–D (1–4), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells.
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