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Biochemical changes in the liver of Swiss albino mice orally exposed to acrylamide

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Author(s): Renu Sharma

Journal: Maejo International Journal of Science and Technology
ISSN 1905-7873

Volume: 2;
Issue: 03;
Start page: 542;
Date: 2008;
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Keywords: acrylamide | GSH | protein | alkaline phosphatase | SGOT | SGPT

ABSTRACT
Acrylamide is a common chemical which is used worldwide to synthesise polyacrylamide. Polyacrylamide and acrylamide both have numerous applications in cosmetic industries, plastic and aesthetic surgeries, ophthalmic operations, waste water treatments, oil recovery processes, and other industrial and laboratory processes. Exposure of mice (Mus musculus) to acrylamide at three dose levels (5, 15 and 25 mg/kg body weight) was investigated for its effects on the liver. Mortality was found to be nil in all the experimental groups. A significant decrease in body weight gain and liver weight was observed but the relative liver weight increased significantly with dose concentration. A significant decrease was observed in protein and GSH levels as compared to those of control, and this reduction was more pronounced at highest dose level. Concentrations of SGOT, SGPT, and serum alkaline phosphatase activity showed a significant increase which was directly proportional to the concentration of the dose.
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