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BIOCHEMICAL ESTIMATIONS IN 6-HYDROXYDOPAMINE-INDUCED RAT MODEL OF PARKINSON’S DISEASE

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Author(s): Alin Ciobica | Lucian Hritcu | Vlad Artenie

Journal: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
ISSN 1582-3571

Volume: 8;
Issue: 2;
Date: 2007;
Original page

ABSTRACT
Although the etiology of Parkinson’s disease (PD) is unknown, a common element of most theories is the involvement of oxidative stress, either as a cause or effect of the disease. There have been relatively few studies that have characterized oxidative stress in animal models of PD. In the present study a 6-hydroxydopamine (6-OHDA) rodent model of PD was used to investigate the in vivo production of oxidative stress after administration of the neurotoxin. 6- OHDA (8µg/4µl) was right-unilateral injected in substantia nigra (SN) and ventral tegmental area (VTA), and 20 days after neurosurgery the activity of superoxid dismutase (SOD) and glutathione peroxidase (GPX) from the temporal lobe homogenate was assessed. A significant decrease in both markers was found in the temporal lobe 20 days after neurotoxin administration. These results support that an early event in the course of dopamine depletion following 6-OHDA administration is the generation of oxidative stress.

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