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Biochemical Evaluation of Combination Drug Interaction Between Phenobarbitone and Halofantrine in Weaning Rats

Author(s): H.C.C. Maduka | A. Salihu | V.A. Onwuliri

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 3;
Issue: 8;
Start page: 711;
Date: 2003;
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Keywords: Phenobarbitone | halofantrine | total protein | monooxygenase | alkaline phosphatase | acid phosphatase | liver | RBC | WBC | HB | PCV | blood | weaning rats

Combination drug interaction between sodium phenobarbitone and halofantrine was studied biochemically in weaning rats. Groups were made according to their body weights. All the rats were sacrificed after 4 days of drug administration and the liver homogenates and blood prepared for biochemical and haematological investigations of cytotoxicity. Results showed that total protein contents, monooxygenase, acid phosphatase and alkaline phosphatase activities in the liver increased with increase in drug administered for all the tests compared with the drug free controls. In the haematological analysis, there was increase down the column with increase in drug for RBC, PCV and Hb while the reverse was the case for WBC (total and differential) compared with the controls. This would suggest that phenobarbitone had an overwhelming sparing effect on the depletion of the haematological parameters and induced their synthesis and lymphocytic maturation but inhibited eosinophil production. The result indicated that phenobarbitone affected the cytotoxic and haematological effects of halofantrine, an antimalarial drug.
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