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Biodegradable Chitosan/Multiwalled Carbon Nanotube Composite for Bone Tissue Engineering

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Author(s): Imelda Olivas-Armendariz | Santos Adriana Martel-Estrada | Mónica E. Mendoza-Duarte | Florinda Jiménez-Vega | Perla García-Casillas | Carlos A. Martínez-Pérez

Journal: Journal of Biomaterials and Nanobiotechnology
ISSN 2158-7027

Volume: 04;
Issue: 02;
Start page: 204;
Date: 2013;
Original page

Keywords: Bone Tissue Regeneration | Chitosan | Multiwalled Carbon Nanotubes | Composite

ABSTRACT
In this work the influence of multiwalled carbon nanotubes (MWCNT) on mechanical properties was evaluated also the osteoinduction mechanism in Chitosan/MWCNT composite is reported. The morphology and the mechanical properties of the scaffolds were controlled by varying solvent ratios, quenching temperatures and carbon nanotubes concentration. In vitro cell culture of Sprague-Dawley rat’s osteoblasts was used to evaluate the phenotype expression of cells in the scaffolds. The presence of MWCNT in a chitosan matrix improving its mechanical properties and sustain osteoblast growth and differentiation that represent a potential application of the Chitosan/MWCNT as biomaterial for bone tissue engineering.
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