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Biodistribution and clearance of instilled carbon nanotubes in rat lung

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Author(s): Elgrabli Dan | Floriani Magali | Abella-Gallart Steve | Meunier Laurent | Gamez Christelle | Delalain Patrice | Rogerieux Fran├žoise | Boczkowski Jorge | Lacroix Ghislaine

Journal: Particle and Fibre Toxicology
ISSN 1743-8977

Volume: 5;
Issue: 1;
Start page: 20;
Date: 2008;
Original page

ABSTRACT
Abstract Background Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. Methods We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated. Results and conclusion Our results in rats that received MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration.
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