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Bioinformatics analysis of metastasis-related proteins in hepatocellular carcinoma

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Author(s): Pei-Ming Song, Yang Zhang, Yu-Fei He, Hui-Min Bao, Jian-Hua Luo, Yin-Kun Liu, Peng-Yuan Yang, Xian Chen

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 14;
Issue: 38;
Start page: 5816;
Date: 2008;
Original page

Keywords: Hepatocellular carcinoma | Metastasis | Bioinformatics | Protein-protein interaction | Kyoto encyclopedia of genes and genomes

ABSTRACT
AIM: To analyze the metastasis-related proteins in hepatocellular carcinoma (HCC) and discover the biomarker candidates for diagnosis and therapeutic intervention of HCC metastasis with bioinformatics tools.METHODS: Metastasis-related proteins were determined by stable isotope labeling and MS analysis and analyzed with bioinformatics resources, including Phobius, Kyoto encyclopedia of genes and genomes (KEGG), online mendelian inheritance in man (OMIM) and human protein reference database (HPRD).RESULTS: All the metastasis-related proteins were linked to 83 pathways in KEGG, including MAPK and p53 signal pathways. Protein-protein interaction network showed that all the metastasis-related proteins were categorized into 19 function groups, including cell cycle, apoptosis and signal transduction. OMIM analysis linked these proteins to 186 OMIM entries.CONCLUSION: Metastasis-related proteins provide HCC cells with biological advantages in cell proliferation, migration and angiogenesis, and facilitate metastasis of HCC cells. The bird’s eye view can reveal a global characteristic of metastasis-related proteins and many differentially expressed proteins can be identified as candidates for diagnosis and treatment of HCC.
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