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Biomarkers of silicosis: Potential candidates

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Author(s): Tiwari R

Journal: Indian Journal of Occupational and Environmental Medicine
ISSN 0973-2284

Volume: 9;
Issue: 3;
Start page: 103;
Date: 2005;
Original page

Keywords: Angiotensin converting enzyme | Biomarkers | Cytokines | Silicosis | Tumor necrosis factor

ABSTRACT
Silica dust is widely prevalent in the atmosphere and more common than the other types of dust, thus making silicosis the most frequently occurring pneumoconiosis. In India also, studies carried out by National Institute of Occupational Health have shown high prevalence of silicosis in small factories and even in nonoccupational exposed subjects. The postero-anterior chest radiographs remain the key tool in diagnosing and assessing the extent and severity of interstitial lung disease. Although Computed Tomography detects finer anatomical structure than radiography it could not get popularity because of its cost. On the basis of histological features of silicosis many potential biomarkers such as Cytokines, Tumor Necrosis Factor, Interleukin 1, Angiotensin Converting Enzyme, Serum Copper, Fas ligand (FasL), etc. have been tried. However, further studies are needed to establish these potential biomarkers as true biomarker of silicosis.
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