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BIOTECHNOLOGY BASED DRUG DELIVERY BY PEGYLATION METHOD

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Author(s): Giri Tapan Kumar | Nashine Jai Prakash | Namdeo Laxmi | Tripathi Dulal Krishna

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 1;
Start page: 95;
Date: 2011;
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Keywords: Protein | peptide | conjugation | growth hormone | graft.

ABSTRACT
PEGylation methods represent promising means for delivering many bioactive agents, including peptide and protein drugs. The importance of these methods grew with the advancement in the understanding of peptide and protein pharmacology as well as the ability to mass-produce these compounds. This polymer is non-toxic, non-immunogenic, non-antigenic, and highly soluble in water and FDA approved. These PEGylation systems have several advantages over conventional methods such as ease of manufacture, ease of administration, a prolonged residence in body, a decreased degradation by metabolic enzyme and a reduction or elimination of protein immunogenicity. In this article, we introduce the different strategies that have been developed and patented for use of poly ethylene glycol (PEG) in delivering peptide and protein drugs. The advantage, disadvantage, possibilities, and limitations of each of the PEGylation systems have been discussed.
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