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Biotinidase Deficiency Accompanying Hair Changes and Periorificial Lesions: A Case Report

Author(s): Erhan Ayhan | Abdullah Kıvrak | Sema Aytekin

Journal: Turk Dermatoloji Dergisi
ISSN 1307-7635

Volume: 5;
Issue: 03;
Start page: 79;
Date: 2011;
Original page

Keywords: Alopecia | biotin | biotinidase deficiency | periorificial dermatitis

Biotinidase deficiency is impairment of biotin metabolism characterized by various dermatological, ophthalmic and neurological symptoms. Autosomal recessive trait is a disorder. Skin findings such as alopecia, periorificial dermatitis and seborrhoeic dermatitis lesions are seen. Clinical signs improved dramatically with biotine treatment. We presented a 6-year-old male patient with periorificial lesions, alopecia and microscopic hair shaft defects.
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