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Biotoxic and Haemotoxic Effects of Air Pollutants at a Benzene Station on Albino Rats

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Author(s): M. Abousalem | A. Elgerwi | A. El-Mashad

Journal: International Journal of Animal and Veterinary Advances
ISSN 2041-2894

Volume: 4;
Issue: 3;
Start page: 187;
Date: 2012;
Original page

Keywords: Benzene | blood | kidney | liver | pollutants | toxic

ABSTRACT
This study was directed to explore the hazardous effect of occupational exposure to air pollutants arised from benzene station. A total of 48 albino rats were calssified into three groups each of sixteen rats. Groups one and two were kept at a benzene station for 60 and 120 days, respectively and the third group was kept as a control under laboratory conditions. After termination of the experiment, animals were sacrificed and blood samples were collected for hematological and biochemical investigations. Sera were separated and used to check the effects of air pollutants arising at a benzene station on the liver and kidney functions as well as on the immune status of the body. Results indicated a pronounced time-dependent reductions in RBCs, Hb, PCV, total and differential (neutrophil and lymphocyte) leucocytic counts. Total protein, albumin, globulin and immunoglobulins IgG, IgA and IgM showed marked lower levels in animals exposed to air pollutants in the benzene station. Organ function tests revealed elevations of the levels of AST, ALT, ALP and GGT that indicate impaired liver function compared to those of the corresponding control. Similar results were recorded for creatinine kinase, urea and creatinine indicating toxic effects on the heart and kidneys.
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