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Biventricular pacing and heterogeneity of ventricular repolarization in heart failure patients

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Author(s): Lucio Santangelo | Vincenzo Russo | Ernesto Ammendola | Ciro Cavallaro | Filippo Vecchione | Salvatore Garofalo | Antonio D'Onofrio | Nicola Minnini | Raffaele Calabrò

Journal: Heart International
ISSN 1826-1868

Volume: 2;
Issue: 1;
Date: 2006;
Original page

Keywords: Biventricular pacing | QT dispersion | JT dispersion | TDR | Heart failure

ABSTRACT
Objective: The aim of our study was to evaluate the effect of cardiac resyncronization therapy (CRT) on QT dispersion (QTd), JT dispersion (JTd) and transmural dispersion of repolarization (TDR), markers of heterogeneity of ventricular repolarization in a study population with severe heart failure. Methods and Results: Fifty patients (43 male, 7 female, aged 60.2 ± 3.1 years) suffering from congestive heart failure (N = 39 NYHA class III; N = 11 NYHA class IV) as a result of coronary artery disease (N = 19) or of dilated cardiomyopathy (N = 31), sinus rhythm, QRS duration >130 ms (mean QRS duration >156 ± 21 ms), an ejection fraction < 35%, left ventricular end-diastolic diameter >55 mm, underwent permanent biventricular DDDR pacemaker implantation. A 12-lead standard electrocardiogram was performed at baseline, during right-, left-, and biventricular pacing and QTd, JTd and TDR were assessed. Biventricular pacing significantly reduced QTd (73.93 ± 19.4 ms during BiVP vs 91 ± 6.7 ms at sinus rhythm, p = 0.004), JTd (73.18 ± 17.16 ms during BiVP vs 100.72 ± 39.04 at baseline p = 0.003), TDR (93.16 ± 15.60 vs 101.55 ± 19.08 at baseline; p

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