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blaCTX-M-2 and blaCTX-M-28 extended-spectrum β-lactamase genes and class 1 integrons in clinical isolates of Klebsiella pneumoniae from Brazil

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Author(s): Ana Catarina S Lopes | Dyana Leal Veras | Alexsandra Mariá S Lima | Rita de Cássia Andrade Melo | Juan Ayala

Journal: Memórias do Instituto Oswaldo Cruz.
ISSN 0074-0276

Volume: 105;
Issue: 2;
Start page: 163;
Date: 2010;
Original page

Keywords: Klebsiella pneumoniae | blaCTX-M | integrons | multidrug resistance

ABSTRACT
Twenty-eight Klebsiella pneumoniae clinical isolates that exhibited an extended-spectrum cephalosporin-resistance profile from a city in the Northeast of Brazil were analysed by PCR and DNA sequencing in order to determine the occurrence of blaCTX-M genes and class 1 integrons. We determined the occurrence of the blaCTX-M-2 gene in six K. pneumoniae isolates and describe the first detection of the blaCTX-M-28 gene in South America. Seven isolates carried class 1 integrons. Partial sequencing analysis of the 5'-3'CS variable region in the class 1 integrons of three isolates revealed the presence of aadA1, blaOXA-2 and dfr22 gene cassettes.
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