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Blood Transfusion In Primary Hip And Knee Arthroplasty. Preoperative Treatment With Recombinant Human Erythropoietin

Author(s): Luis A. Gómez-Navalón*, Pedro Zorrilla*, Antonio Marín*, Cristóbal Martínez*, Jose A. Salido*

Journal: Journal of Orthopaedics
ISSN 0972-978X

Volume: 4;
Issue: 4;
Date: 2007;
Original page

Keywords: Blood Transfusion | Knee Arthroplasty. | Erythropoietin

Joint prosthetic surgery, particularly of the hip and knee, is one of the most common orthopedic procedures performed today. The increase in life expectancy and an aging population demanding an increasingly higher quality of life are factors that have contributed to this phenomenon. This type of surgery is known to cause a loss of blood that often requires a blood transfusion,1 which is not without potential risks and complications such as transmission of infectious diseases (mainly hepatitis and AIDS),2,3 manipulation errors, fever, increased rate of infections, etc., without forgetting that a proportion of the population refuses to have a blood transfusion because of religious beliefs.4 In order to palliate these problems, it is attempted to reduce blood transfusion needs as much as possible by various procedures, including preoperative autologous blood donation, the use of blood recovery systems, agents that reduce bleeding, minimally invasive surgery and stimulation of erythrocyte production with erythropoietin (EPO) among others. The present study analyzed the reduction in transfusion requirements achieved by preoperative administration of EPO in patients undergoing primary hip and knee arthroplasty.
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