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Bone Morphogenic Protein: Current State of Field and the Road Ahead

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Author(s): Dr. Vaibhav Bagaria

Journal: Journal of Orthopaedics
ISSN 0972-978X

Volume: 2;
Issue: 4;
Date: 2005;
Original page

Keywords: Bone morphogenic protein | Spine fusion | Fracture healing | Bone regeneration | rh BMP 2 | OP –1

ABSTRACT
Bone morphogenic proteins (BMP) have shown significant potential in enhancing spinal fusions and bone formation at non-union sites. Animal studies and limited human studies have proven their efficacy as an alternative or enhancer of autologus bone graft in bone regeneration. Optimal dose and carrier especially in complex scenarios like recalcitrant non unions posterolateral spinal fusion still remain an important issue where the use of BMP has not been entirely successful. Their use in fields like articular regeneration, joint replacement and chronic renal failure is also being aggressively investigated. This review article intends to give brief information on the biology and basic science behind BMPs and provide an update on the current research data on various clinical applications of BMPs.
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