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Bootstrap calibration of TRANSMIT for informative missingness of parental genotype data

Author(s): Allen Andrew | Collins Julianne | Rathouz Paul | Selander Craig | Satten Glen

Journal: BMC Genetics
ISSN 1471-2156

Volume: 4;
Issue: Suppl 1;
Start page: S39;
Date: 2003;
Original page

Abstract Informative missingness of parental genotype data occurs when the genotype of a parent influences the probability of the parent's genotype data being observed. Informative missingness can occur in a number of plausible ways and can affect both the validity and power of procedures that assume the data are missing at random (MAR). We propose a bootstrap calibration of MAR procedures to account for informative missingness and apply our methodology to refine the approach implemented in the TRANSMIT program. We illustrate this approach by applying it to data on hypertensive probands and their parents who participated in the Framingham Heart Study.
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