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Bosentan and sildenafil in the treatment of HIV-associated pulmonary hypertension

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Author(s): Pierangelo Chinello | Stefania Cicalini | Andrea Cortese | Maria Paola Cicini | Nicola Petrosillo

Journal: Infectious Disease Reports
ISSN 2036-7430

Volume: 3;
Issue: 2;
Start page: e14;
Date: 2011;
Original page

Keywords: bosentan | sildenafil | HIV | pulmonary arterial hypertension

ABSTRACT
We present the case of an HIV/HCV-coinfected patient with HIV-related pulmonary hypertension (HRPH) who experienced a good clinical and functional response to bosentan, with a subsequent switch to oral sildenafil due to increased transaminase levels. Bosentan resulted less handy in this case, probably due to both side effects and co-morbidities.
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