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C-511T Polymorphism of Interleukin-1 β Gene is Not Associated in Type 2 Diabetes Mellitus-A Study in Malaysian Population

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Author(s): R. Vasudevan | Patimah Ismail | Johnson Stanslas | Norashikin Shamsudin

Journal: Journal of Medical Sciences
ISSN 1682-4474

Volume: 8;
Issue: 3;
Start page: 216;
Date: 2008;
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Keywords: Cytokines | interleukin -1 β gene | Type 2 Diabetes Mellitus | polymorphism | PCR-RFLP

ABSTRACT
The objective of this study is to determine the association between the C-511T polymorphism of Interleukin -1 β gene in T2DM with or without hypertension in Malaysian population. A total of 175 subjects were recruited for this study. Genotyping of C-511T variant was performed by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM, 25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67% respectively found in controls (p>0.05). This study suggests that there was no significant difference in the genotypic distribution of C-511T polymorphism of IL-1 β gene between T2DM and controls. Therefore, C-511T variant in IL-1 β gene polymorphism is not considered an independent risk factor or not a predictor for T2DM in Malaysian population.
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