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C-fos protein expression in the parietal cortex and olfactory tubercle in the hypoxic rat brain

Author(s): Puškaš Laslo | Puškaš Nela | Babović Siniša S. | Velicki Lazar | Ivanov Dejan | Mijatov-Ukropina Ljilja

Journal: Medicinski Pregled
ISSN 0025-8105

Volume: 60;
Issue: 3-4;
Start page: 128;
Date: 2007;
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Keywords: hypoxia | brain | rats | proto-oncogene proteins c-fos | parietal lobe | olfactory pathways

Introduction. We have attempted to identify which parts of the brain react to ischemic attack using the four-vessel occlusion model in rats. Material and methods. We have monitored the expression of c-fos protein in the parietal cortex (R3 and T3) and in the olfactory tubercle (R4 and T4), regions which are supplied with blood by different arteries. The four-vessel occlusion was performed using the Pulsinelli’s method and rats were divided into two groups: total ischemia (ligation of four blood vessels or coagulation of the vertebral artheries with bilateral ligation of carotid arteries - R group) and transient ischemic attack (ligation of four blood vessels or coagulation of the vertebral arteries with bilateral repeated ligation of carotid arteries - T group of rats, the so- called preconditioned group). Each of these groups had a control group. Results and conclusion. The results showed pronounced expression of c-fos neurons in T group of rats which can explain longer survival of neurons. We believe that this model can serve as a good starting point to developing new approaches to the therapy of brain ischemia.
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