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Cambios histológicos en pulmón de ratas intoxicadas con Paraquat y tratadas con vitamina E y dexametasona

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Author(s): Glenda Landaeta | Yolima Fernández | Rosalía Sutil | Yalitza Aular | Mercedes Márquez | Aldo Reigosa | Maria E Gómez | Marielena Muñoz

Journal: Salus Online
ISSN 1316-7138

Volume: 12;
Issue: 2;
Start page: 69;
Date: 2008;
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Keywords: Paraquat | histological changes in lung | vitamin E | dexametasone

ABSTRACT
Paraquat: PQ (1.1 dimetil-4-4-bipiridilo) is an agricultural herbicide, whose poisoning unleashes a series of histological pulmonary injuries. Vitamin E (VE) is a biological antioxidant which sweeps away free radicals. Dexametasone (DMX) has an anti inflammatory action. In the present work, the histological changes in lung of rats poisoned with PQ and treated with VE, DMX and related substances were evaluated. Sprague-Dawley rats were divided into six groups (G): G1 (Negative Control) 6 rats that received saline solution; G2 (Positive control) 6 rats that received (PQ) 11 mg/kg i.p; G3: 8 rats pretreated 10 days before the poisoning with oral VE 500 mg/Kg; G4: 8 rats poisoned with PQ + VE; G5: 8 rats that received IM PQ + DMX 1 mg/kg; and G6: 8 rats that received PQ + VE + DMX. The experimental period lasted 31 days. The G2 rats that received PQ died within 48 hours; whereas G3, G4, G5 and G6 survived 294, 504, 438, 300 hours, respectively. The histopathological analysis revealed severe pulmonary damage produced by PQ, which was lessened by treatment with VE, DMX and related substances. Results suggest a possible protective effect of such medicines on the oxidative damage induced by the herbicide.
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