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Camparision Results of Administration of Glucoseamine and Glucoseamine with Alendronate in Symptomatic Relieve of Knee DJD

Author(s): Hamid Reza Arti | Seyed Abdolhossin Mehdinasab | Naser Sarafan

Journal: Jundishapur Scientific Medical Journal
ISSN 2252-052X

Volume: 11;
Issue: 5;
Start page: 467;
Date: 2012;
Original page

Keywords: Alendronate | Glocoseamine | Osteoarthritis.

Background and Objective: Degenerative Joint disease(DJD) is the most common joint disease in human and the most cause of chronic disability in aging papulation in developed countries. Several studies explain that glocosamine Is better than plasebo and its efficacy is more in comparison with NSAID in knee osteoarthritic patient.Alendronate is prescribed for osteoprothic patients. The aim of this study was to compare the efficacy of adminstration of glocoseamine alone and in combination with alendronate in osteoarthritis of the knee.Subjects and Methods: A total of 130 patients of either sex with osteoarthritis were included in the study and randomised to receive glocoseamine alone (500mg TDS) and combination of Glocoseamine (500mg TDS) and alendronate (70mg weeky) for 12weeks. The patients were evaluated at 1;3;6 and 12weeks for efficacy.Results: There was not statisticaly significant decrease in pain index (p>0.05) but in total therapy the mean of pain is decreased.The stiffnes index in combination therapy was decreased (p
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