Academic Journals Database
Disseminating quality controlled scientific knowledge

Cardioprotective Activity of Fruit of Lagenaria siceraria (Molina) Standley on Doxorubicin Induced Cardiotoxicity in Rats

ADD TO MY LIST
 
Author(s): M. Hassanpour Fard | S.L. Bodhankar | Madhumira Dikshit

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 4;
Issue: 6;
Start page: 466;
Date: 2008;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Lagenaria siceraria | doxorubicin | electrocardiogram | cardioprotective activity

ABSTRACT
The aim of present study was to investigate the cardioprotective effect of Lagenaria siceraria (LS) fruit powder against the cardiotoxicity of doxorubicin (Dox) in rats. Male wistar rats (250-300 g) were randomly divided into three groups. Group 1-was control (gum acacia 2%), group 2-Dox (10 mg kg-1), group 3-Dox+LS (200 mg kg-1 for 18 days). Dox (10 mg kg-1 i.v.) was administered in group 2 and 3 on day 16. After anesthetizing the animals on the 18th day, electrocardiogram (ECG) was recorded and blood was investigated for creatine kinase-MB isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) while determination of superoxide dismutase (SOD), reduced glutathione (GSH), lipid peroxidation (LPO) and histopathology was carried out for heart. Group 3 animals showed decreased QT and ST intervals (p
Affiliate Program     

Tango Rapperswil
Tango Rapperswil