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Cardioprotective Activity of Fruit of Lagenaria siceraria (Molina) Standley on Doxorubicin Induced Cardiotoxicity in Rats

Author(s): M. Hassanpour Fard | S.L. Bodhankar | Madhumira Dikshit

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 4;
Issue: 6;
Start page: 466;
Date: 2008;
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Keywords: Lagenaria siceraria | doxorubicin | electrocardiogram | cardioprotective activity

The aim of present study was to investigate the cardioprotective effect of Lagenaria siceraria (LS) fruit powder against the cardiotoxicity of doxorubicin (Dox) in rats. Male wistar rats (250-300 g) were randomly divided into three groups. Group 1-was control (gum acacia 2%), group 2-Dox (10 mg kg-1), group 3-Dox+LS (200 mg kg-1 for 18 days). Dox (10 mg kg-1 i.v.) was administered in group 2 and 3 on day 16. After anesthetizing the animals on the 18th day, electrocardiogram (ECG) was recorded and blood was investigated for creatine kinase-MB isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) while determination of superoxide dismutase (SOD), reduced glutathione (GSH), lipid peroxidation (LPO) and histopathology was carried out for heart. Group 3 animals showed decreased QT and ST intervals (p
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