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Cardioprotective effect of black cumin on isoproterenol-induced myocardial infarction in rats

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Author(s): Ragunath Muthu, Murugesan Madhesh, Sakthivel Malaiyandi, Manju Vaiyapuri*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 7;
Start page: 2040;
Date: 2011;
Original page

Keywords: Migrain | Antiserotonergic activity | Abrus precatorius | sumatriptan.

ABSTRACT
To study the effect of Black cumin on isoproterenol induced myocardial infarction in rats. Four groups of rats each comprising of ten animals were selected for this study. Group I served as control and group II animals were given isoproterenol (85 mg/kg body weight intraperitoneally (i.p), group III animals were orallyadministered Black cumin (150 mg/kg body weight) for 15 days. Group 1V animals received both Black cumin (50 mg/kg body weight) and isoproterenol (at the end of the treatment) for 15 days. Group V animals received both Black cumin (100 mg/kg body weight) and isoproterenol (at the end of the treatment) for 15 days. Group VI animals received both Black cumin (150 mg/kg body weight) and isoproterenol (at the end of the treatment) for 15 days. Thiobarbituric acid reactive substances (TBARS). The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) in both serum and heart tissue were estimated. Isoproterenol was indicated by elevated levels of lipid peroxidation markers such as thiobarbutric acid reactivesubstances (TBARS). Administration of Black cumin at dose 150 mg/kg body weight by intragastric intubation for 15 days prevented the above changes and improved towards normally. The activities of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) significantly decreased in the plasma, erythrocyte and tissue of isoproterenol induced myocardial infarction in rats. The study confirms the protective effect of Black cumin on isoproterenol inducedmyocardial infarction in rats.
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