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A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-γ

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Author(s): Mamishi Setareh | Zomorodian Kamiar | Saadat Farshid | Gerami-Shoar Mohsen | Tarazooie Bita | Siadati Seyad Ahmad

Journal: Annals of Clinical Microbiology and Antimicrobials
ISSN 1476-0711

Volume: 4;
Issue: 1;
Start page: 4;
Date: 2005;
Original page

ABSTRACT
Abstract Background Chronic granulomatous disease (CGD) is a rare disorder of phagocytes in which absence of superoxide and hydrogen peroxide production in phagocytes predisposes patients to bacterial and fungal infections. The most common fungal infections in these patients are caused by Aspergillus species. Case presentation Here, we describe Aspergillus osteomyelitis of the ribs and hepatic abscess in a 5-year-old boy. The patient was successfully treated with Amphotericin B and INF-γ. Conclusion With respect to the high frequency of aspergillosis in the CGD patient, immune deficiency should be investigated in patients with invasive aspergillosis. Moreover, using antifungal drugs as prophylaxis can improve the quality of life in these patients.
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