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A catalytic method for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents

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Author(s): Yahia Sh. Beheshtia | Maliheh Khorshidi | Majid M. Heravi | Bita Baghernejad

Journal: Bulletin of the Chemical Society of Ethiopia
ISSN 1011-3924

Volume: 24;
Issue: 3;
Start page: 433;
Date: 2010;
Original page

Keywords: 3-Cyano-2(1H)-pyridinones | 2-Imino | Cardiotonic | Dimethoxyacetophenone

ABSTRACT
A highly efficient procedure for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres via a one-pot multicomponent reaction of 3,4-dimethoxyacetophenone, malonitrile or ethyl cyanoacetate, an aldehyde and ammonium acetate in the presence of K2CO3 is achieved in good yields.
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