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Catecholaminergic polymorphic ventricular tachycardia in 2012

Author(s): Ineke Nederend | Christian van der Werf | Arthur A.M. Wilde

Journal: Cardiogenetics
ISSN 2035-8253

Volume: 1;
Issue: 1s;
Start page: e4;
Date: 2011;
Original page

Keywords: catecholaminergic polymorphic ventricular tachycardia | sudden cardiac death | genetics | channelopathies.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare, potentially lethal inherited arrhythmia syndrome characterized by stress or emotion-induced ventricular arrhythmias. CPVT was first described in 1960, while the genetic basis underlying this syndrome was discovered in 2001. The past decade has seen substantial advances in understanding the pathophysiology of CPVT. In addition, significant advances have been made in elucidating clinical characteristics of CPVT patients and new treatment options have become available. Here, we review current literature on CPVT to present state-of-the-art knowledge on the subject of the genetic basis, pathophysiology, clinical presentation, diagnosis, treatment and prognosis.
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