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Caudal epidural sufentanil and bupivacaine decreases stress response in paediatric cardiac surgery

Author(s): Sendasgupta Chaitali | Makhija Neeti | Kiran Usha | Choudhary Shiv | Lakshmy R | Das Sambhu

Journal: Annals of Cardiac Anaesthesia
ISSN 0971-9784

Volume: 12;
Issue: 1;
Start page: 27;
Date: 2009;
Original page

Keywords: Caudal | CPB | paediatric | stress response

Surgery and anaesthesia are known to cause stress response. Attenuation of stress response can decrease morbidity, postoperative hospital length of stay and, thus, cost. Intrathecal and epidural techniques produce reliable analgesia in patients undergoing surgery along with stress response attenuation. The present study was undertaken to evaluate the efficacy of caudal sufentanil and bupivacaine combination on perioperative stress response in paediatric patients undergoing open heart surgery. Thirty patients (ASA grade II-III) undergoing elective corrective cardiac surgery for acyanotic congenital heart disease, were randomly allocated to two groups. In group GA ( n = 15), patients received balanced general anaesthesia. In group GC ( n = 15), in addition to general anaesthesia, caudal block with bupivacaine and sufentanil combination was given after endotracheal intubation. Monitoring included electrocardiography, invasive arterial pressure, end-tidal carbon dioxide, pulse oximetry, arterial blood gases including serum electrolytes, blood glucose, serum cortisol, urine output, central venous pressure and temperature. Haemodynamic responses in both groups were statistically similar. Serum cortisol levels were significantly lower in GC group than GA group ( P