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CD4⁺Foxp3⁺ Treg and its ICOS⁺ Subsets in Patients with Myocardial Infarction

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Author(s): Samira Ghorbani Gazar | Alireza Andalib | Mohamad Hashemi | Abbas Rezaei

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 9;
Issue: 1;
Start page: 53;
Date: 2012;
Original page

Keywords: Acute Coronary Syndrome | Atherosclerosis | ICOS | Myocardial Infarction | Regulatory T Cells | Stable Angina

ABSTRACT
Background: Atherosclerosis is a multifactorial disorder with chronic inflammatoryconditions in which immune cells play a significant role in its pathogenic process.Regulatory T cells (Treg), as a part of immune system, are involved in controlling autoimmuneand inflammatory diseases. Quantitative and/or functional alteration of Tregshas been shown to play an atheroprotective role and may also promote plaque stabilization.Objective: To assess if inducible costimulatory molecule (ICOS) expression onone subtype of Treg cells with high suppressive potential correlates with the pathogenesisof atherosclerosis. Methods: Patients with myocardial infarction (MI) and/or stableangina (SA), diagnosed as atherosclerosis by angiography, and a group of individualswith normal coronary angiography (NCA) were recruited for the present study. Peripheralblood mononuclear cells (PBMCs) were prepared and the expression of ICOS,Foxp3 and CD4 molecules was tested by flowcytometry. Results: The percentage ofCD4+Foxp3+ Treg cells was reduced in MI group compared to NCA and SA groups(p
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