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Cechy kliniczne choroby afektywnej dwubiegunowej występujące rodzinnie – przesłanka do badań genetyczno-molekularnych

Author(s): Joanna Hauser

Journal: Neuropsychiatria i Neuropsychologia
ISSN 1896-6764

Volume: 2;
Issue: 1;
Start page: 37;
Date: 2007;
Original page

Keywords: bipolar affective disorders | phenotype | family study | linkage analysis | association studies

Epidemiological studies suggest that individual variationin susceptibility to bipolar affective disorder (BP) islargely genetic, reflecting alleles of moderate effect inmultiple genes. Molecular genetic studies have identifiedseveral potential regions of linkage, but specific genesthat contribute to the illness remain unclear. Progressin identifying the genetic basis of bipolar affectivedisorder has been disappointing probably because ofgenetic and phenotypic heterogeneity of this illness. Itis highly likely that using alternative phenotypes insteadof only DSM and ICD diagnostic criteria will lead morerapid success in the search for susceptibility genes. BPis clinically heterogeneous, and clinical features that runin families may help define more homogeneousphenotypes. The objective of this paper is to describeclinical phenotypes that can be employed in psychiatricgenetic studies of BP. Linkage and association studiesare summarized in reference to subtypes of BP.

Tango Jona
Tangokurs Rapperswil-Jona

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