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Cells Attachment Property of PVA Hydrogel Nanofibers Incorporating Hyaluronic Acid for Tissue Engineering

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Author(s): Kyu-Oh Kim | Yaeko Akada | Wei Kai | Byoung-Suhk Kim | Ick-Soo Kim

Journal: Journal of Biomaterials and Nanobiotechnology
ISSN 2158-7027

Volume: 02;
Issue: 04;
Start page: 353;
Date: 2011;
Original page

Keywords: Nanofiber | Electrospinning | Hydrogel | Poly(Vinyl Alcohol) | Hyaluronic Acid | Cell Affinity

ABSTRACT
In this work, we report the fabrication and cell affinity studies of the poly(vinyl alcohol) (PVA)/hyaluronic acid (HA) cross-linked nanofibers via electrospinning and post cross-linking. FT-IR and TGA analysis demonstrate that HA is not influenced by acid environment such as HCl vapor during cross-linking, and well incorporated into PVA nanofibers. Swelling behavior and cell adhesion of the PVA/HA hydrogel nanofibers are investigated and compared with pure PVA hydrogel nanofibers. It is expected that the nanofibrous PVA/HA hydrogel fibers could be a promising scaffold for cell culture and tissue engineering applications.
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