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Cellular Interaction around Capillaries in Different Parts of Heart at Myocardial Infarction

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Author(s): Dmitriy V. Kozlov | Yulia S. Korneva | Alexander E. Dorosevich

Journal: International Journal of Collaborative Research on Internal Medicine & Public Health
ISSN 1840-4529

Volume: 3;
Issue: 3;
Start page: 281;
Date: 2011;
Original page

Keywords: Myocardial infarction | cell populations | morphometry

ABSTRACT
Background: The problem of high mortality from myocardial infarction (MI) is very actual all over theworld in spite of the progress in diagnostic and treatment. The great amount of investigations is directedto cell therapy, which is focused on the correction of cell populations in hurried and intact zones tostimulate reparation. In this work the investigation has been done according to the study of perivascularcommunicative systems.Materials and methods: 73 hearts of dead people from MI were investigated. According to themorphology and multiplicity, they were divided into 6 groups: acute (AMI) and recurrent (RMI) MI withprescription 1-2 days (AMI-1, RMI-1); 3-5 days (AMI-2, RMI-2); more than 5 days (AMI-3, RMY-3).During the autopsy samples of cardiac muscle 1 cm 3 in capacity were cut from the centre of necrotic zone(LV-1), demarcation zone (LV-2). We accepted the center of interventricular septum (IS) as intact zone .The material was microscopically analyzed with Hematoxylin and Eosin and morphometric accountingof cells of stroma was done. For statistical treatment non parametric methods were used: U-test andSpearmen rank correlation coefficient. Probability values
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