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Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum

Author(s): Shih-Tseng Lin | Shang-Kwei Wang | Chang-Yih Duh

Journal: Marine Drugs
ISSN 1660-3397

Volume: 9;
Issue: 12;
Start page: 2705;
Date: 2011;
Original page

Keywords: soft coral | Lobophytum crassum | cytotoxicity

Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A–C (1–3) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 1–4 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED50 of 3.6 μg/mL.

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