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Central activities of Pimenta pseudocaryophyllus (Gomes) L.R. Landrum

Author(s): James Oluwagbamigbe FAJEMIROYE | José Luís Rodrigues MARTINS | Adriane Ferreira de BRITO | Pablinny Moreira GALDINO | José Realino de PAULA | Joelma Abadia Marciano de PAULA | Elson Alves COSTA

Journal: International Journal of Medicinal and Aromatic Plants
ISSN 2249-4340

Volume: 2;
Issue: 1;
Start page: 118;
Date: 2012;
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Keywords: Behavioural alterations | Pimenta pseudocaryophyllus | Anxiolytic-like

Folkloric medicinal application of Pimenta pseudocaryophyllus popularly known as “craveiro” as calming agent is a commonplace in Campos do Jordão, SP, Brazil. Pharmacological screening of ethanolic leaf extract of Pimenta pseudocaryophyllus (EEPp) and its active fraction (s) for possible anxiolytic like effect became necessary in order to confirm its therapeutic claims by the populace. Preliminary investigation with oral administration of EEPp (0.5, 1.0 and 2.0 g/kg) was devoid of any sign of neurotoxicity. In barbiturate induced – hypnosis, EEPp 1.0 g/kg potentiated the pentobarbital-induced sleep (32% reduction in sleep latency and 20% increase in sleep duration) while only dichloromethane and aqueous fractions increases sleep duration. Based on the parameters evaluated in both the open field and light dark box models, only dichloromethane fraction among others showed consistent anxiolytic like effect.
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