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CENTRAL NERVOUS SYSTEM ACTIVITY OF DIFFERENT EXTRACTS OF LAGENARIA SICERARIA (MOL)STANDL. LEAVES PARTS

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Author(s): Jayashree C. Pawar

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 7;
Start page: 9;
Date: 2010;
Original page

Keywords: Lagenaria siceraria | Analgesic | Motor coordination | CNS-depression

ABSTRACT
Lagenaria siceraria(Mol) Standl.is commomn plant in India. It is considered laxative, cardiotonic, diuretic, bitter, emetic, lessen inflammation. In the present study, crude petroleum ether(PE), chloroform (CE) and methanol extract (ME)of Leaves of Lagenaria siceraria have been evaluated for analgesic (100, 200 mg/kg, i.p.) and central nervous system (CNS)depressant activity (100, 200 mg/kg, i.p.).The analgesic activity was assayed in several experimental models: acetic acid induced writhing (chemically induced pain), hot plate, tail flick test (thermally induced pain). Among the three extracts, petroleum ether, methanol and chloroform extract shows significant analgesic activity but Petroleum ether extract shows maximum analgesia among them. These statements indicate the presence of CNS active drugs present in leaf part of plant. The petroleum ether extract and methanolic extract significantly and in dose dependent manner reduce the nociception induced by acetic acid. In hot plate and tail flick test methanolic and petroleum ether extract shows more significant action than chloroform extract. In the study of the CNS-depressant effect, the methanolic extract significantly reduces spontaneous motor activity at higher doses than petroleum ether extract. The fall off time (motor coordination) was also decreased. A potentiation in the pentobarbitone-induced sleep due to the sedative effect of the methanolic extract was observed. The result shows that petroleum ether extract and methanolic extract shows analgesic and CNS-depressant activity may be because of presence of different chemical compounds present in that extracts. Further investigations are, however, necessary to explore mechanism(s) of action involved in these pharmacological activities.

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