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Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C

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Author(s): Roberto J Carvalho-Filho | Janaína Luz Narciso-Schiavon | Luciano HL Tolentino | Leonardo L Schiavon | Maria Lucia G Ferraz | Antonio Eduardo B Silva

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 18;
Issue: 2;
Start page: 188;
Date: 2012;
Original page

Keywords: Hepatitis C | Central nervous system | Polyneuropathy | Interferon-α

ABSTRACT
Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients. However, central nervous system (CNS) involvement is uncommon, especially in cryoglobulin-negative subjects. We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia. Significant improvement was observed after antiviral therapy. We discuss the spectrum of neurological manifestations of HCV infection and review the literature.
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