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Changes in antioxidants and lipid peroxidation in workers of a pesticide production factory

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Author(s): H.R Joshaghani | A.R Ahmadi

Journal: Journal of School of Public Health and Institute of Public Health Research
ISSN 1735-7586

Volume: 6;
Issue: 3-4;
Start page: 41;
Date: 2008;
Original page

Keywords: Glutathione peroxidase | Superoxide dismutase | Total antioxidants | Malondialdehyde | Organophosphate

ABSTRACT
Background and Aim: Organophosphate compoounds are cholinesterase activity inhibitors. Contact with them cause changes in the blood antioxidant enzyme levels and lipid peroxidation. The aim of this research was to investigate the simultaneous changes in cholinesterase, total serum antioxidant levels, and activities of some of the erythrocyte antioxidant enzymes and find possible correlations among these variables in pesticide factory workers. "nMaterials and Methods: This research was a cohort study carried out, during 2006, on the employees of a pesticide factory in Golestan Province, Iran. Blood samples were taken at the beginning (n=81 subjects) and after 3 months (n=63, of the initial 81). Erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant levels were determined enzymatically (Randox, UK) and serum SOD was measured by the ELISA method (IBL, Germany). For the determination of malondialdehyde (MDA) a chemical method (based on thiobarbituric acid) was used. Confidence interval was 95% for all statistical tests."nResults: Levels of serum and erythrocyte SOD, serum MDA, and both serum and eryhthrocyte GPx significantly increased (paired t-test, p
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