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Changes in cerebral perfusion detected by dynamic susceptibility contrast magnetic resonance imaging: normal volunteers examined during normal breathing and hyperventilation

Author(s): Ronnie Wirestam | Christian Engvall | Erik Ryding | Stig Holtas | Freddy Stahlberg | Peter Reinstrup

Journal: Journal of Biomedical Science and Engineering
ISSN 1937-6871

Volume: 02;
Issue: 04;
Start page: 210;
Date: 2009;
Original page

Keywords: Magnetic Resonance Imaging | Perfusion | Cerebral Blood Flow | Mean Transit Time | Hypocapnia

Global cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) de-creased during hyperventilation in all volun-teers (average decrease 29%), and the corre-sponding global CBF estimates were 73±19ml/ (min100g) during normal breathing and 52± 7.9ml/(min100g) during hyperventilation (mean ±SD, n=8). Furthermore, the hypocapnic condi-tions induced by hyperventilation resulted in a prolongation of the global mean transit time (MTT) by on average 14%. The observed CBF estimates appeared to be systematically over-estimated, in accordance with previously pub-lished DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.
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